IVIG & GVH

IVIG Sites of Interest:
Patient Notification System for the Plasma Products Industry This service notifies registrants of recalls and withdrawals of plasma products including IVIG.
How to keep an infusion log
 PDF format – Very important information.  All users of  IVIG should keep their own infusion log.
Availability of Immune Globulin Intravenous for Treatment of Immune Deficient Patients–United States
Home therapy with subcutaneous immunoglobulin infusions in children with congenital immunodeficiencies
Intravenous Immunoglobulins: Viral Safety
Immune Globulin Products


IVIG Products:
Gamunex

Gammagard and Gammagard SD
Flebogamma
Hizentra
Octagam
Privigen 
Vivaglobulin

Graft Vs. Host Disease:
Graft-vs-host disease (GvHD) is a complication that is observed after allogeneic stem cell / bone marrow transplant. GvHD occurs when infection-fighting cells from the donor recognize the patient’s body as being different or foreign. These infection-fighting cells then attack tissues in the patient’s body just as if they were attacking an infection. The tissues most affected by bone marrow GvHD are the skin, the liver, and the intestines. GvHD is categorized as acute when it occurs within the first 100 days after transplantation and chronic if it occurs more than 100 days after transplantation.
What is Graft vs. Host Disease?
Graft Vs. Host Disease

Transfusion Associated GvHD: Graft vs. host disease is a rare complication of blood transfusion. The disease results from transfusion of immunocompetent T cells capable of engrafting and initiating an immune response against recipient antigens. The most susceptible patient groups are those who are severely immunocompromised. Gamma irradiation abolishes the proliferative activity of the lymphocytes in the donor blood. Fresh frozen plasma and cryoprecipitate do not contain viable lymphocytes and thus do not need to be irradiated. “It is recommended that patients with immunodeficiencies such as Di George Syndrome, Wiskott Aldrich, and SCID receive only irradiated blood products.”