What is the Cd5 - Cd19 PID?

In 1997, Dr. Robert W. Hostoffer DO, pediatric immunologist from Cleveland, Ohio,  made a remarkable break through in the discovery of an astonishing Primary Immune Deficiency. The syndrome, which was given the name Cd5 - Cd19 PID, involves a complete and total lack of response to polysaccharide antibodies and an extremely high expression of Cd5+ B-cells. It has been documented that the lack of antibody response is due to an insufficient number of Cd5- cells in these patients. At this time, it is also suspected that the defect is T-cell related.  Presently, there are only 7 boys in the world diagnosed with this very rare syndrome. Although research continues, to date, no females or adults have been identified with this immune deficiency.

The following is from a case study written by Peter M. Antall, MD, Howard Meyerson, MD, David Kaplan, MD, John Venglarcik, MD, and Robert W. Hostoffer, DO Cleveland and Youngstown, Ohio, and published in  The Journal of Allergy and Clinical Immunology, April 1999, pages 637-641, Volume 103, Number 4;  . 

"Primary humoral deficiencies vary from complete absence of B cells and/or serum immunoglobulin to lacunar deficits involving specific antibody responses to polysaccharides." 

Only a short abstract of this article is available online.  It is recommended that anyone researching this subject obtain the complete article. 

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This page last updated 09/08/2002